PIK3C2G

Across TCGA pan-cancer cohorts, PIK3C2G Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PIK3C2G data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PIK3C2G Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3C2G expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THCA, LUSC, and ESCA are the cancer types where PIK3C2G Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.027	0.945	<.001	24	view →
LUSC	OS	Median	II,III,IV	0.327	0.625	.008	20	view →
ESCA	OS	Median	II,III,IV	0.278	0.691	.011	18	view →
OV	OS	Median	II,III,IV	0.368	0.692	.044	12	view →
BLCA	OS	Median	All	0.234	0.691	.009	12	view →
ACC	OS	Median	All	0.287	0.809	.001	12	view →
UCEC	DFS	Median	All	0.842	0.626	.013	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →
KIRP	OS	Median	All	0.256	0.696	.028	2	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PIK3C2G–THCA (DFS)

Open the THCA breakdown →