PIK3AP1

Across TCGA pan-cancer cohorts, PIK3AP1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PIK3AP1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where PIK3AP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PIK3AP1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, COAD, and CCRCC are the cancer types where PIK3AP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3AP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.598	<.001	8	view →
COAD	Female	III,IV	+0.490	.006	7	view →
CCRCC	Male	II,III,IV	+0.357	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PIK3AP1–PDAC

Open the PDAC breakdown →