PIK3AP1

Across TCGA patient cohorts, PIK3AP1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3AP1-associated genes across cancer lineages are C-Raf, JNK_pT183_Y185, and ATM. Each is linked with PIK3AP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3AP1-to-partner and partner-to-PIK3AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by PIK3AP1-low versus PIK3AP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3AP1→partner) and Y-score (partner→PIK3AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.161	+2.841	.019	.033	3	3
UCEC	JNK_pT183_Y185 →	-0.161	-1.874	.001	.002	3	3
UCEC	ATM →	-0.335	-1.986	.012	.008	3	3
UCEC	JNK2 →	+0.154	+1.594	.008	.010	3	2
UCEC	p62 Lck ligand →	+0.281	+2.584	.003	<.001	3	2
UCEC	PDCD4 →	-0.343	-1.415	.013	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

C-Raf by PIK3AP1 expression — COAD

Explore this box plot interactively →