PIK3AP1

Across TCGA cell cohorts, PIK3AP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,987 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PIK3AP1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Toll-like receptor 2 signaling pathway, and Nucleoside triphosphate metabolic process. Each is linked with PIK3AP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PIK3AP1-to-partner and partner-to-PIK3AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by PIK3AP1-low versus PIK3AP1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3AP1→partner) and Y-score (partner→PIK3AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.094	+0.445	<.001	<.001	3	7
SOFT_TISSUE	Toll-like receptor 2 signaling pathway →	-0.171	-1.063	<.001	<.001	3	7
BREAST	Nucleoside triphosphate metabolic process →	+0.077	+0.375	<.001	.001	3	7
BREAST	Nucleoside triphosphate biosynthetic process →	+0.071	+0.387	<.001	<.001	3	7
LUNG_SCLC	Nucleotide biosynthetic process →	+0.058	+0.805	<.001	.001	3	7
STOMACH	Collagen fibril organization →	-0.201	-1.704	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,987 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by PIK3AP1 expression — BREAST

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