PIK3AP1

Across TCGA cell cohorts, PIK3AP1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PIK3AP1-associated genes across cancer lineages are IL36B, MT1B, and IFNA7. Each is linked with PIK3AP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3AP1-to-partner and partner-to-PIK3AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36B grouped by PIK3AP1-low versus PIK3AP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3AP1→partner) and Y-score (partner→PIK3AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL36B →	+0.032	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MT1B →	+1.176	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	IFNA7 →	+0.035	+5.643	<.001	.002	3	1
LARGE_INTESTINE	ANO5 →	+0.713	+3.453	<.001	.009	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
SKIN	SPACA1 →	+0.161	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IL36B by PIK3AP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →