PIH1D1

Across TCGA pan-cancer cohorts, PIH1D1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIH1D1 data layer compared with 18 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIH1D1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIH1D1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where PIH1D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.964	0.546	.001	52	view →
LSCC	DFS	Median	II,III,IV	0.819	0.556	.021	6	view →
CCRCC	OS	Median	III,IV	0.485	1.000	.036	4	view →
LUAD	OS	Quartile	III,IV	0.767	0.222	.035	4	view →
GBM	DFS	Quartile	All	0.629	0.829	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIH1D1–PDAC (OS)

Open the PDAC breakdown →