PIH1D1

Across TCGA pan-cancer cohorts, PIH1D1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PIH1D1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIH1D1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIH1D1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where PIH1D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIH1D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.483	<.001	11	view →
COAD	Male	IV	+0.852	<.001	10	view →
LIHC	Female	II,III,IV	+1.074	<.001	9	view →
BLCA	All	All	+0.641	<.001	8	view →
STAD	All	II,III,IV	+0.628	<.001	8	view →
HNSC	All	All	+0.267	.003	8	view →
LUAD	All	III,IV	+0.496	<.001	7	view →
KICH	Female	All	−0.984	<.001	6	view →
UCEC	All	All	+0.391	.006	6	view →
CHOL	Male	All	+1.660	<.001	5	view →
LUSC	All	All	+0.474	<.001	5	view →
READ	All	II,III,IV	+0.415	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PIH1D1–KIRC

Open the KIRC breakdown →