PIH1D1

Across TCGA patient cohorts, PIH1D1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIH1D1-associated genes across cancer lineages are Notch1, ASNS, and ATM. Each is linked with PIH1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIH1D1-to-partner and partner-to-PIH1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PIH1D1-low versus PIH1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIH1D1→partner) and Y-score (partner→PIH1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.192	+2.335	.002	.018	3	2
UCEC	ASNS →	+0.409	+2.459	.012	.019	3	2
UCEC	ATM →	-0.478	-2.986	.019	.035	3	2
UCEC	EGFR_pY1068 →	-0.243	-2.700	.031	.006	3	1
UCEC	ACC1 →	+0.336	+3.013	.040	.018	3	1
UCEC	JNK2 →	+0.343	+3.026	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Notch1 by PIH1D1 expression — UCEC

Explore this box plot interactively →