PIH1D1

Across TCGA cell cohorts, PIH1D1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIH1D1-associated genes across cancer lineages are SLC32A1, SCGB1D1, and A3GALT2. Each is linked with PIH1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIH1D1-to-partner and partner-to-PIH1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by PIH1D1-low versus PIH1D1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIH1D1→partner) and Y-score (partner→PIH1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.535	+3.901	.002	.006	3	1
BLOOD_Leukemia	SCGB1D1 →	+0.054	+4.384	<.001	.006	3	1
BLOOD_Leukemia	A3GALT2 →	+0.027	+4.133	.001	.003	3	1
BLOOD_Leukemia	LCE2A →	+0.042	+4.384	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SLC32A1 by PIH1D1 expression — BLOOD_Leukemia

Explore this box plot interactively →