PIGS

Across TCGA pan-cancer cohorts, PIGS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIGS data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIGS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIGS expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where PIGS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.629	1.000	.002	22	view →
PDAC	OS	Quartile	All	0.396	0.569	.015	12	view →
UCEC	DFS	Quartile	All	0.818	1.000	.017	4	view →
LUAD	DFS	Median	III,IV	0.709	0.285	.026	4	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIGS–CCRCC (OS)

Open the CCRCC breakdown →