PIGS

Across TCGA pan-cancer cohorts, PIGS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIGS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIGS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIGS is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where PIGS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.872	<.001	12	view →
KICH	Male	All	−1.885	<.001	11	view →
BLCA	All	III,IV	+0.727	<.001	9	view →
COAD	Female	II,III,IV	−0.647	<.001	8	view →
LIHC	Female	II,III,IV	+1.330	<.001	7	view →
CHOL	Female	All	+3.260	<.001	5	view →
LUSC	Female	All	+0.834	<.001	5	view →
STAD	Male	II,III,IV	+0.605	.007	4	view →
THCA	Male	III,IV	−0.517	.002	4	view →
KIRC	Male	II,III,IV	−0.405	.005	4	view →
READ	All	All	−0.637	.008	2	view →
BRCA	All	III,IV	+0.420	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIGS–HNSC

Open the HNSC breakdown →