PIGS

Across TCGA patient cohorts, PIGS mutation is significantly associated with the RNA expression of many other genes, with 1,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGS-associated genes across cancer lineages are RNU6-694P, RN7SKP218, and KRTAP19-11P. Each is linked with PIGS in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGS-to-partner and partner-to-PIGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by PIGS-low versus PIGS-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGS→partner) and Y-score (partner→PIGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-694P →	+0.331	+5.039	<.001	.009	3	2
STAD	RN7SKP218 →	+0.310	+4.219	.005	.009	3	2
STAD	KRTAP19-11P →	+0.418	+4.567	<.001	.008	3	2
STAD	MTCO3P41 →	+0.372	+4.520	<.001	.005	3	2
STAD	RNU6-165P →	+0.629	+4.363	<.001	.007	3	2
UCEC	KRTAP23-1 →	+0.212	+2.717	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,337 associations by consensus.

RNU6-694P by PIGS expression — LGG

Explore this box plot interactively →