PIGS

Across TCGA patient cohorts, PIGS mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGS-associated genes across cancer lineages are ERK2, Heregulin, and IGFBP2. Each is linked with PIGS in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGS-to-partner and partner-to-PIGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PIGS-low versus PIGS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGS→partner) and Y-score (partner→PIGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.254	+2.459	.006	.020	3	1
UCEC	Heregulin →	-0.149	-2.459	.012	.020	3	1
UCEC	IGFBP2 →	-0.683	-3.000	.029	.036	2	2
UCEC	JNK_pT183_Y185 →	-0.236	-3.169	.003	.019	3	1
UCEC	PEA-15 →	+0.185	+2.459	.041	.020	3	1
UCEC	STAT3_pY705 →	-0.442	-3.159	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ERK2 by PIGS expression — UCEC

Explore this box plot interactively →