PIGS

Across TCGA cell cohorts, PIGS mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIGS-associated genes across cancer lineages are OR2L8, HRG, and MAGEB4. Each is linked with PIGS in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGS-to-partner and partner-to-PIGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L8 grouped by PIGS-low versus PIGS-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGS→partner) and Y-score (partner→PIGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
BLOOD_Leukemia	HRG →	+0.444	+3.855	<.001	.007	3	1
BLOOD_Leukemia	MAGEB4 →	+0.037	+3.705	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.082	+3.855	<.001	.007	3	1
BLOOD_Leukemia	CYP4A11 →	+0.029	+3.705	<.001	.007	3	1
BLOOD_Leukemia	OR5H6 →	+0.341	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2L8 by PIGS expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →