PIGR

Across TCGA patient cohorts, PIGR protein abundance is significantly associated with the RNA expression of many other genes, with 12,026 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGR-associated genes across cancer lineages are LRG1, FAM3D, and PLEKHS1. Each is linked with PIGR in more than 6 cancer types. Because this analysis shows association rather than direction, both PIGR-to-partner and partner-to-PIGR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGR versus LRG1 in OV, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGR→partner) and Y-score (partner→PIGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRG1 →	+2.227	+1.641	<.001	<.001	3	7
PDAC	FAM3D →	+1.746	+1.079	<.001	<.001	3	6
UCEC	PLEKHS1 →	+1.547	+1.049	<.001	<.001	3	6
LUAD	NR3C2 →	+0.818	+0.896	<.001	<.001	3	6
LSCC	SLC44A4 →	+1.531	+0.555	<.001	<.001	3	6
COAD	SIAE →	+0.698	+0.877	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,026 associations by consensus.

PIGR vs LRG1 — OV

Explore this scatter interactively →