PIGR

Across TCGA patient cohorts, PIGR mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGR-associated genes across cancer lineages are eIF4G, ERK2, and GAPDH. Each is linked with PIGR in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGR-to-partner and partner-to-PIGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by PIGR-low versus PIGR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGR→partner) and Y-score (partner→PIGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.234	+2.115	.022	.016	3	2
UCEC	ERK2 →	+0.169	+1.765	.007	.013	3	2
UCEC	GAPDH →	+0.358	+2.000	.042	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.207	-3.087	<.001	<.001	3	2
SKCM	Ku80 →	+0.237	+2.000	.028	.029	3	2
UCEC	STAT3_pY705 →	-0.387	-2.159	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eIF4G by PIGR expression — UCEC

Explore this box plot interactively →