PIGR

Across TCGA cell cohorts, PIGR RNA expression is significantly associated with the go_rna of many other GO terms, with 1,520 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PIGR-associated GO terms across cancer lineages are Negative regulation of myeloid leukocyte mediated immunity, Basement membrane disassembly, and Negative regulation of mast cell degranulation. Each is linked with PIGR in more than 8 cancer types. Because this analysis shows association rather than direction, both PIGR-to-partner and partner-to-PIGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myeloid leukocyte mediated immunity grouped by PIGR-low versus PIGR-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGR→partner) and Y-score (partner→PIGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of myeloid leukocyte mediated immunity →	+1.571	+1.302	<.001	.004	3	9
PANCREAS	Basement membrane disassembly →	+1.617	+1.485	<.001	<.001	3	8
PANCREAS	Negative regulation of mast cell degranulation →	+1.330	+1.461	<.001	.003	3	8
LIVER	Negative regulation of hippocampal neuron apoptotic process →	+1.490	+0.317	<.001	.009	2	9
LUNG_NSCLC_LUAD	Response to mycotoxin →	+0.603	+0.774	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of sodium ion transport →	+0.190	+2.427	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,520 associations by consensus.

Negative regulation of myeloid leukocyte mediated immunity by PIGR expression — PANCREAS

Explore this box plot interactively →