PIGR

Across TCGA cell cohorts, PIGR mutation is significantly associated with the RNA expression of many other genes, with 183 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGR-associated genes across cancer lineages are PGK2, MMP27, and BPIFB6. Each is linked with PIGR in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGR-to-partner and partner-to-PIGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGK2 grouped by PIGR-low versus PIGR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGR→partner) and Y-score (partner→PIGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	BPIFB6 →	+0.047	+4.969	<.001	.003	3	1
BLOOD_Leukemia	DEFB4B →	+0.234	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.061	+4.539	<.001	.007	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 183 associations by consensus.

PGK2 by PIGR expression — SOFT_TISSUE

Explore this box plot interactively →