PIGQ

Across TCGA patient cohorts, PIGQ mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGQ-associated genes across cancer lineages are eIF4E, PKC-b-II_pS660, and NDRG1_pT346. Each is linked with PIGQ in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGQ-to-partner and partner-to-PIGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PIGQ-low versus PIGQ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGQ→partner) and Y-score (partner→PIGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.215	+3.169	.014	.018	3	3
SKCM	PKC-b-II_pS660 →	-0.384	-3.000	.008	.035	3	2
SKCM	NDRG1_pT346 →	-0.683	-2.321	.037	.035	3	1
SKCM	p21 →	-0.528	-3.000	.014	.034	3	1
SKCM	Stathmin →	+0.233	+2.321	.008	.035	3	1
SKCM	XRCC1 →	+0.178	+2.321	.043	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by PIGQ expression — SKCM

Explore this box plot interactively →