PIGQ

Across TCGA pan-cancer cohorts, PIGQ RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PIGQ data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher PIGQ RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PIGQ expression acts as an unfavorable survival marker, although some lineages such as DLBC and PCPG show a favorable association.

DLBC, LGG, and PCPG are the cancer types where PIGQ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.922	0.586	.002	43	view →
LGG	DFS	Median	All	0.295	0.454	<.001	41	view →
PCPG	DFS	Median	All	1.000	0.682	.002	23	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	22	view →
OV	OS	Median	IV	0.474	0.291	.023	20	view →
KIRP	DFS	Tertile	All	0.674	0.380	.013	18	view →
LIHC	DFS	Quartile	All	0.390	0.611	.001	18	view →
LUSC	DFS	Quartile	All	0.292	0.434	.031	12	view →
KICH	DFS	Median	II,III,IV	1.000	0.518	.021	10	view →
THYM	DFS	Tertile	All	0.917	0.651	.015	9	view →
ACC	DFS	Tertile	IV	0.593	0.065	.024	6	view →
SKCM	DFS	Tertile	All	0.158	0.327	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PIGQ–DLBC (DFS)

Open the DLBC breakdown →