PIGQ

Across TCGA cell cohorts, PIGQ mutation is significantly associated with the RNA expression of many other genes, with 225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGQ-associated genes across cancer lineages are TBATA, FAM47A, and PADI6. Each is linked with PIGQ in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGQ-to-partner and partner-to-PIGQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBATA grouped by PIGQ-low versus PIGQ-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGQ→partner) and Y-score (partner→PIGQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBATA →	+0.184	+3.544	<.001	.009	3	2
LUNG_NSCLC_LUAD	FAM47A →	+0.051	+3.734	.001	.006	3	1
LUNG_NSCLC_LUAD	PADI6 →	+0.051	+3.866	<.001	.006	3	1
STOMACH	DMRTB1 →	+1.551	+3.807	.004	.005	3	1
STOMACH	FAM9A →	+0.025	+3.432	.003	.008	3	1
STOMACH	TFDP3 →	+0.024	+3.632	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

TBATA by PIGQ expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →