PIGPP4

Across TCGA patient cohorts, PIGPP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,135 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PIGPP4-associated GO terms across cancer lineages are Negative regulation of DNA metabolic process, Methylation, and Protein-RNA complex organization. Each is linked with PIGPP4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PIGPP4-to-partner and partner-to-PIGPP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA metabolic process grouped by PIGPP4-low versus PIGPP4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGPP4→partner) and Y-score (partner→PIGPP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of DNA metabolic process →	+0.071	+0.106	<.001	<.001	3	10
STAD	Methylation →	+0.077	+0.151	<.001	<.001	3	9
STAD	Protein-RNA complex organization →	+0.095	+0.125	<.001	<.001	3	9
STAD	RNA capping →	+0.090	+0.119	<.001	<.001	3	9
STAD	Transcription initiation at RNA polymerase II promoter →	+0.090	+0.133	<.001	<.001	3	9
STAD	snRNA modification →	+0.070	+0.125	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,135 associations by consensus.

Negative regulation of DNA metabolic process by PIGPP4 expression — STAD

Explore this box plot interactively →