PIGO

Across TCGA patient cohorts, PIGO mutation is significantly associated with the RNA expression of many other genes, with 4,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGO-associated genes across cancer lineages are HNRNPCP1, WDR41, and SAAL1. Each is linked with PIGO in more than 3 cancer types. Because this analysis shows association rather than direction, both PIGO-to-partner and partner-to-PIGO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPCP1 grouped by PIGO-low versus PIGO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGO→partner) and Y-score (partner→PIGO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HNRNPCP1 →	+0.532	+3.321	<.001	<.001	3	4
UCEC	WDR41 →	+0.458	+2.099	<.001	<.001	3	4
UCEC	SAAL1 →	+0.452	+2.475	<.001	<.001	3	4
GBM	FABP5P15 →	+0.534	+5.149	<.001	.007	3	3
UCEC	KLHL28 →	+0.407	+2.110	.001	<.001	3	3
UCEC	CYB5D1 →	+0.345	+3.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,996 associations by consensus.

HNRNPCP1 by PIGO expression — UCEC

Explore this box plot interactively →