PIGO

Across TCGA patient cohorts, PIGO mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGO-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PDCD4, and Caspase-7-cleavedD198. Each is linked with PIGO in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGO-to-partner and partner-to-PIGO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PIGO-low versus PIGO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGO→partner) and Y-score (partner→PIGO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.380	-1.379	.010	.019	3	3
UCEC	PDCD4 →	-0.534	-2.502	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.808	+2.824	.030	.034	3	3
UCEC	mTOR_pS2448 →	-0.114	-1.886	.020	.015	3	2
UCEC	Annexin-1 →	+0.576	+2.107	<.001	.002	3	2
UCEC	ATM →	-0.498	-3.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

p38-MAPK_pT180_Y182 by PIGO expression — UCEC

Explore this box plot interactively →