Across TCGA patient cohorts, PIGN RNA expression is significantly associated with the protein abundance of many other proteins, with 15,179 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGN-associated proteins across cancer lineages are SMAD4, CTDP1, and TXNL1. Each is linked with PIGN in more than 7 cancer types. Because this analysis shows association rather than direction, both PIGN-to-partner and partner-to-PIGN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGN→partner) and Y-score (partner→PIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMAD4 →	+0.322	+0.773	<.001	<.001	3	8
COAD	CTDP1 →	+0.355	+0.703	<.001	<.001	3	7
OV	TXNL1 →	+0.434	+0.642	<.001	<.001	3	6
OV	NARS1 →	+0.471	+0.659	<.001	<.001	3	6
LSCC	NEDD4L →	+0.459	+0.556	<.001	<.001	3	6
BRCA	RPRD1A →	+0.416	+0.638	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,179 associations by consensus.

Exploration

PIGN survival (RNA) · tumor vs normal (RNA) · all PIGN data types