Across TCGA patient cohorts, PIGN protein abundance is significantly associated with the RNA expression of many other genes, with 3,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGN-associated genes across cancer lineages are DSCAML1, RELCH, and VPS4B. Each is linked with PIGN in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGN-to-partner and partner-to-PIGN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGN→partner) and Y-score (partner→PIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DSCAML1 →	-1.384	-0.261	<.001	.004	3	3
HNSC	RELCH →	+0.387	+0.290	.006	.003	3	3
OV	VPS4B →	+0.462	+0.274	<.001	<.001	3	2
OV	TESMIN →	-0.789	-0.395	<.001	.001	3	2
OV	MBD2 →	+0.428	+0.218	<.001	.008	3	2
LSCC	SLC39A6 →	+0.590	+0.489	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,520 associations by consensus.

Exploration

PIGN survival (RNA) · tumor vs normal (RNA) · all PIGN data types