Across TCGA patient cohorts, PIGN mutation is significantly associated with the RNA expression of many other genes, with 1,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGN-associated genes across cancer lineages are TSPY9P, CDY3P, and APOOP4. Each is linked with PIGN in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGN-to-partner and partner-to-PIGN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGN→partner) and Y-score (partner→PIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TSPY9P →	+0.075	+6.709	<.001	<.001	3	3
SKCM	CDY3P →	+0.012	+4.993	<.001	.002	3	3
SKCM	APOOP4 →	+0.059	+3.766	<.001	.005	3	3
LIHC	OR6U2P →	+0.118	+5.108	.002	.008	3	2
LIHC	PPIHP2 →	+0.143	+5.447	<.001	.005	3	2
READ	RNU6-940P →	+0.472	+6.681	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,600 associations by consensus.

Exploration

PIGN survival (RNA) · tumor vs normal (RNA) · all PIGN data types