Across TCGA patient cohorts, PIGN mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGN-associated genes across cancer lineages are A-Raf_pS299, p27_pT157, and Tuberin_pT1462. Each is linked with PIGN in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGN-to-partner and partner-to-PIGN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGN→partner) and Y-score (partner→PIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.209	-3.700	<.001	.001	3	2
UCEC	p27_pT157 →	-0.065	-2.867	.005	.001	3	2
UCEC	Tuberin_pT1462 →	+0.344	+2.584	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.700	.006	.006	3	1
UCEC	eIF4E →	+0.189	+1.906	.025	.016	3	1
UCEC	GSK-3_pS9 →	+0.391	+2.415	.016	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

PIGN survival (RNA) · tumor vs normal (RNA) · all PIGN data types