Across TCGA cell cohorts, PIGN mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGN-associated genes across cancer lineages are PRAMEF33, KCNA5, and CCL13. Each is linked with PIGN in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGN-to-partner and partner-to-PIGN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGN→partner) and Y-score (partner→PIGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF33 →	+0.326	+4.029	<.001	<.001	3	2
OESOPHAGUS	KCNA5 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	CCL13 →	+0.049	+4.906	<.001	.006	3	1
OESOPHAGUS	CXorf51B →	+0.133	+4.906	<.001	.006	3	1
LUNG_SCLC	MMP20 →	+0.039	+4.781	.001	<.001	3	1
LUNG_SCLC	CST2 →	+0.042	+3.232	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

Exploration

PIGN survival (RNA) · tumor vs normal (RNA) · all PIGN data types