PIGM

Across TCGA patient cohorts, PIGM protein abundance is significantly associated with the RNA expression of many other genes, with 6,148 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGM-associated genes across cancer lineages are SLX4IP, ADAM17, and PIAS2. Each is linked with PIGM in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGM-to-partner and partner-to-PIGM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGM versus SLX4IP in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGM→partner) and Y-score (partner→PIGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLX4IP →	+0.614	+0.923	.005	.002	3	3
OV	ADAM17 →	+0.650	+0.632	.001	.004	3	3
UCEC	PIAS2 →	+0.789	+1.057	.006	.005	3	3
GBM	CYTH4 →	-0.947	-0.364	.001	.001	3	3
GBM	CSF2RB →	-0.904	-0.330	<.001	.001	3	3
GBM	STAB1 →	-1.023	-0.284	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,148 associations by consensus.

PIGM vs SLX4IP — UCEC

Explore this scatter interactively →