PIGM

Across TCGA pan-cancer cohorts, PIGM RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PIGM’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PIGM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIGM is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, LIHC, and KICH are the cancer types where PIGM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.014	<.001	10	view →
LIHC	Male	All	+1.350	<.001	9	view →
KICH	Male	All	−1.335	<.001	9	view →
LUAD	Male	II,III,IV	+0.858	<.001	9	view →
HNSC	All	All	+0.469	<.001	8	view →
COAD	Male	All	+0.578	<.001	7	view →
BRCA	All	III,IV	+1.051	<.001	6	view →
STAD	Male	II,III,IV	+0.849	<.001	6	view →
CHOL	All	All	+1.848	<.001	5	view →
THCA	Male	All	−0.373	.017	5	view →
UCEC	All	All	+0.713	<.001	4	view →
LUSC	All	All	+0.453	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PIGM–BLCA

Open the BLCA breakdown →