PIGM

Across TCGA patient cohorts, PIGM protein abundance is significantly associated with the protein abundance of many other proteins, with 7,822 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIGM-associated proteins across cancer lineages are SEC22A, SMPD4, and PIGX. Each is linked with PIGM in more than 4 cancer types. Because this analysis shows association rather than direction, both PIGM-to-partner and partner-to-PIGM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIGM versus SEC22A in UCEC, with a Pearson correlation of 0.68.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGM→partner) and Y-score (partner→PIGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC22A →	+1.078	+1.712	<.001	<.001	3	4
UCEC	SMPD4 →	+0.519	+0.985	<.001	<.001	3	4
BRCA	PIGX →	+1.038	+1.397	<.001	<.001	3	3
UCEC	ATP7A →	+0.458	+1.249	<.001	<.001	3	3
LSCC	ALG3 →	+0.633	+0.388	<.001	<.001	3	3
LSCC	GPRIN3 →	-0.364	-0.447	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,822 associations by consensus.

PIGM vs SEC22A — UCEC

Explore this scatter interactively →