PIGM

Across TCGA patient cohorts, PIGM mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGM-associated genes across cancer lineages are Smad4, ASNS, and PDK1. Each is linked with PIGM in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGM-to-partner and partner-to-PIGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by PIGM-low versus PIGM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGM→partner) and Y-score (partner→PIGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad4 →	-0.144	-2.980	.039	.036	3	1
UCEC	ASNS →	+0.542	+3.000	.009	.037	3	1
UCEC	PDK1 →	-0.140	-3.000	.024	.037	2	1
UCEC	Tuberin_pT1462 →	+0.355	+2.817	.007	.036	2	1
UCEC	p27_pT198 →	+0.166	+3.000	.007	.037	1	1
UCEC	TAZ →	-0.167	-3.000	.041	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Smad4 by PIGM expression — UCEC

Explore this box plot interactively →