PIGK

Across TCGA pan-cancer cohorts, PIGK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIGK data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIGK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIGK expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where PIGK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.637	1.000	.002	28	view →
COAD	DFS	Median	All	1.000	0.919	.013	24	view →
HNSC	DFS	Tertile	All	0.331	0.889	.010	19	view →
PDAC	DFS	Tertile	All	0.661	0.848	.014	2	view →
LUAD	OS	Tertile	All	0.891	0.653	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIGK–CCRCC (OS)

Open the CCRCC breakdown →