PIGK

Across TCGA pan-cancer cohorts, PIGK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIGK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIGK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIGK is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where PIGK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.657	<.001	11	view →
KICH	Female	II,III,IV	−1.872	<.001	10	view →
THCA	Male	III,IV	−0.929	<.001	10	view →
KIRC	Male	III,IV	−0.468	<.001	8	view →
LIHC	Female	All	+0.635	<.001	7	view →
LUSC	All	All	−0.235	.004	5	view →
STAD	All	II,III,IV	+0.571	.003	4	view →
CHOL	All	All	+1.457	<.001	3	view →
UCEC	All	All	−0.514	.023	2	view →
KIRP	All	All	−0.359	.007	2	view →
BLCA	Male	IV	−0.427	.048	1	view →
LUAD	Female	II,III,IV	−0.321	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIGK–HNSC

Open the HNSC breakdown →