PIGK

Across TCGA patient cohorts, PIGK mutation is significantly associated with the RNA expression of many other genes, with 2,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGK-associated genes across cancer lineages are RNU6-75P, LIN7C, and COX15. Each is linked with PIGK in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGK-to-partner and partner-to-PIGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-75P grouped by PIGK-low versus PIGK-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGK→partner) and Y-score (partner→PIGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-75P →	+0.608	+5.925	<.001	.002	3	2
UCEC	LIN7C →	+0.613	+3.130	<.001	<.001	3	2
UCEC	COX15 →	+0.368	+2.095	.002	.003	3	2
UCEC	DLAT →	+0.599	+2.939	<.001	<.001	3	2
UCEC	C18orf25 →	+0.460	+2.917	<.001	<.001	3	2
UCEC	RAD17 →	+0.454	+2.436	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,570 associations by consensus.

RNU6-75P by PIGK expression — READ

Explore this box plot interactively →