PIGK

Across TCGA patient cohorts, PIGK mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGK-associated genes across cancer lineages are MEK1, eEF2, and eIF4E. Each is linked with PIGK in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGK-to-partner and partner-to-PIGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PIGK-low versus PIGK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGK→partner) and Y-score (partner→PIGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.506	+3.321	<.001	<.001	3	2
UCEC	eEF2 →	+0.391	+1.807	.003	.025	3	1
UCEC	eIF4E →	+0.218	+2.662	.005	<.001	3	1
UCEC	Heregulin →	-0.115	-1.861	.013	.049	3	1
UCEC	IGFBP2 →	-0.499	-1.765	.040	.014	3	1
UCEC	INPP4B →	-0.319	-2.906	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by PIGK expression — UCEC

Explore this box plot interactively →