PIGK

Across TCGA cell cohorts, PIGK mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGK-associated genes across cancer lineages are DMRTB1, C1orf189, and PPDPFL. Each is linked with PIGK in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGK-to-partner and partner-to-PIGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by PIGK-low versus PIGK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGK→partner) and Y-score (partner→PIGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	2
LARGE_INTESTINE	C1orf189 →	+0.132	+3.376	<.001	.002	3	1
LARGE_INTESTINE	PPDPFL →	+0.034	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ARGFX →	+0.008	+3.700	<.001	.009	3	1
BLOOD_Lymphoma	NCBP2L →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRT25 →	+0.537	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DMRTB1 by PIGK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →