PIGF

Across TCGA patient cohorts, PIGF mutation is significantly associated with the RNA expression of many other genes, with 131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGF-associated genes across cancer lineages are PRAMEF13, MIR133B, and PRAMEF28P. Each is linked with PIGF in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGF-to-partner and partner-to-PIGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF13 grouped by PIGF-low versus PIGF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGF→partner) and Y-score (partner→PIGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRAMEF13 →	+0.670	+5.797	<.001	.001	3	2
LUSC	MIR133B →	+0.228	+7.924	<.001	.008	3	2
SKCM	PRAMEF28P →	+0.231	+4.867	<.001	.005	3	2
BLCA	MIR5681A →	+0.272	+7.640	<.001	.009	3	1
SKCM	MRPL50P1 →	+0.104	+5.328	<.001	.003	3	1
UCEC	SNRNP25 →	+0.602	+3.397	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

PRAMEF13 by PIGF expression — SKCM

Explore this box plot interactively →