PIGF

Across TCGA pan-cancer cohorts, PIGF RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PIGF data layer compared with 1 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PIGF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGF expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

CESC, LIHC, and ACC are the cancer types where PIGF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.645	0.851	<.001	82	view →
LIHC	OS	Median	All	0.386	0.620	<.001	81	view →
ACC	DFS	Median	All	0.249	0.646	<.001	71	view →
KICH	OS	Tertile	All	0.521	1.000	<.001	71	view →
UVM	DFS	Tertile	III,IV	0.228	0.750	.003	64	view →
KIRC	DFS	Tertile	All	0.867	0.676	<.001	61	view →
SCLC	DFS	Quartile	III,IV	0.271	0.705	.002	57	view →
KIRP	OS	Median	III,IV	0.264	0.647	.003	51	view →
HNSC	DFS	Quartile	All	0.513	0.691	<.001	43	view →
LUAD	DFS	Tertile	II,III,IV	0.370	0.706	.004	28	view →
LGG	OS	Median	All	0.860	0.928	<.001	20	view →
OV	DFS	Tertile	IV	0.413	0.215	.011	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PIGF–CESC (DFS)

Open the CESC breakdown →