PIGF

Across TCGA patient cohorts, PIGF mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGF-associated genes across cancer lineages are Caveolin-1, Rab11, and Notch1. Each is linked with PIGF in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGF-to-partner and partner-to-PIGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by PIGF-low versus PIGF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGF→partner) and Y-score (partner→PIGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caveolin-1 →	-0.798	-3.169	.045	.019	3	1
UCEC	Rab11 →	-0.186	-2.980	.019	.036	2	1
UCEC	Notch1 →	+0.236	+3.169	.002	.020	1	1
UCEC	Tuberin_pT1462 →	+0.267	+3.169	.035	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Caveolin-1 by PIGF expression — UCEC

Explore this box plot interactively →