PIGC

Across TCGA cell cohorts, PIGC mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIGC-associated genes across cancer lineages are DEFA4, AVPR1B, and CFHR2. Each is linked with PIGC in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGC-to-partner and partner-to-PIGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by PIGC-low versus PIGC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGC→partner) and Y-score (partner→PIGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	AVPR1B →	+0.021	+3.716	.008	.003	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	DAZ3 →	+0.022	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DEFA4 by PIGC expression — LARGE_INTESTINE

Explore this box plot interactively →