PIGB

Across TCGA pan-cancer cohorts, PIGB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIGB data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PIGB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIGB expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, GBM, and HNSC are the cancer types where PIGB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.265	0.626	.002	33	view →
GBM	DFS	Quartile	All	0.236	0.523	.020	6	view →
HNSC	OS	Tertile	III,IV	0.632	1.000	.026	4	view →
LSCC	DFS	Median	III,IV	0.988	0.556	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIGB–PDAC (OS)

Open the PDAC breakdown →