PIF1

Across TCGA pan-cancer cohorts, PIF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIF1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher PIF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIF1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and PDAC are the cancer types where PIF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.585	0.277	.027	5	view →
LUAD	DFS	Tertile	II,III,IV	0.810	0.395	.024	3	view →
PDAC	DFS	Median	III,IV	0.510	0.825	.009	3	view →
HNSC	OS	Median	All	0.603	0.852	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIF1–GBM (OS)

Open the GBM breakdown →