PIF1

Across TCGA pan-cancer cohorts, PIF1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PIF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIF1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where PIF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.318	<.001	12	view →
BLCA	Male	All	+1.761	<.001	11	view →
COAD	Female	II,III,IV	+1.482	<.001	11	view →
LUAD	Male	III,IV	+1.221	<.001	11	view →
KIRC	Male	IV	+0.524	<.001	9	view →
LUSC	Male	III,IV	+2.014	<.001	8	view →
STAD	Male	II,III,IV	+1.171	<.001	8	view →
LIHC	Female	II,III,IV	+1.164	<.001	8	view →
KIRP	All	All	+0.279	<.001	8	view →
UCEC	All	II,III,IV	+2.205	<.001	6	view →
BRCA	All	II,III,IV	+0.754	<.001	6	view →
CHOL	Male	All	+2.388	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PIF1–HNSC

Open the HNSC breakdown →