PIF1

Across TCGA patient cohorts, PIF1 mutation is significantly associated with the RNA expression of many other genes, with 2,223 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIF1-associated genes across cancer lineages are NDUFA8, CD24P1, and RNA5SP414. Each is linked with PIF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIF1-to-partner and partner-to-PIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA8 grouped by PIF1-low versus PIF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIF1→partner) and Y-score (partner→PIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFA8 →	+0.551	+3.341	<.001	.005	3	3
COAD	CD24P1 →	+0.432	+5.942	<.001	<.001	3	3
UCEC	RNA5SP414 →	+0.594	+2.255	<.001	.004	3	2
UCEC	MRPL18 →	+0.567	+3.711	<.001	<.001	3	2
UCEC	C3 →	-1.669	-2.321	.001	.006	3	2
UCEC	ANP32B →	+0.453	+3.601	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,223 associations by consensus.

NDUFA8 by PIF1 expression — SKCM

Explore this box plot interactively →