PIF1

Across TCGA patient cohorts, PIF1 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PIF1-associated genes across cancer lineages are Skeletal muscle, Th2 cells, and GMP. Each is linked with PIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIF1-to-partner and partner-to-PIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skeletal muscle grouped by PIF1-low versus PIF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIF1→partner) and Y-score (partner→PIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Skeletal muscle →	+0.040	+2.591	.020	.006	3	2
SKCM	Th2 cells →	+0.177	+3.706	.025	<.001	3	2
LUSC	GMP →	+0.063	+4.264	.002	.024	3	1
SKCM	CD8+ naive T-cells →	-0.029	-2.565	.035	.011	3	1
SKCM	Pericytes →	+0.056	+3.146	.007	<.001	3	1
UCEC	Endothelial cells →	-0.039	-4.044	.013	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Skeletal muscle by PIF1 expression — SKCM

Explore this box plot interactively →