PIF1

Across TCGA cell cohorts, PIF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,747 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIF1-associated GO terms across cancer lineages are Mitotic spindle elongation, DNA integrity checkpoint signaling, and Mitotic spindle midzone assembly. Each is linked with PIF1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PIF1-to-partner and partner-to-PIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle elongation grouped by PIF1-low versus PIF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIF1→partner) and Y-score (partner→PIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic spindle elongation →	+0.257	+1.765	.004	<.001	3	20
OESOPHAGUS	DNA integrity checkpoint signaling →	+0.102	+1.585	<.001	.001	3	20
BONE	Mitotic spindle midzone assembly →	+0.257	+1.765	.004	<.001	3	20
BONE	DNA replication →	+0.151	+1.905	<.001	<.001	3	20
BONE	Double-strand break repair →	+0.105	+1.988	<.001	<.001	3	20
PANCREAS	Cell cycle checkpoint signaling →	+0.092	+1.229	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,747 associations by consensus.

Mitotic spindle elongation by PIF1 expression — BONE

Explore this box plot interactively →