PIF1

Across TCGA cell cohorts, PIF1 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PIF1-associated genes across cancer lineages are CACNA1S, OR9K2, and SRARP. Each is linked with PIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIF1-to-partner and partner-to-PIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA1S grouped by PIF1-low versus PIF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIF1→partner) and Y-score (partner→PIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CACNA1S →	+0.495	+4.392	.001	<.001	3	2
PANCREAS	OR9K2 →	+0.010	+4.614	<.001	.004	3	1
PANCREAS	SRARP →	+0.006	+4.491	<.001	.003	3	1
PANCREAS	TDRD15 →	+0.390	+4.614	<.001	.004	3	1
OVARY	SULT2A1 →	+0.500	+4.263	<.001	.002	3	1
OVARY	CCDC182 →	+0.088	+3.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

CACNA1S by PIF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →