PIEZO2

Across TCGA patient cohorts, PIEZO2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIEZO2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and mTOR_pS2448. Each is linked with PIEZO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIEZO2-to-partner and partner-to-PIEZO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PIEZO2-low versus PIEZO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO2→partner) and Y-score (partner→PIEZO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.534	-1.371	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.467	+1.263	<.001	.014	3	3
LUSC	mTOR_pS2448 →	-0.257	-2.294	.001	.035	3	2
UCEC	eEF2 →	+0.217	+1.440	.010	.020	3	2
UCEC	GAPDH →	+0.276	+1.125	.030	.025	3	2
COAD	JNK_pT183_Y185 →	-0.287	-2.991	.033	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by PIEZO2 expression — UCEC

Explore this box plot interactively →